Université Libre de Bruxelles
Belgium-based work comprised organic synthesis, anticancer metal complexes and halogen bonding. Currently focused on DFT-derived reaction mechanisms of organocatalytic processes, the development of novel lipophilic metal-arene Os/Ru complexes to treat glioblastoma, and the experimental and theoretical assessment of halogen-bonded supramolecular complexes.
My PhD research was about the asymmetric synthesis of 15N-enriched chiral vicinal diamines and their use as ligands for cytotoxic platinum(II) complexes. Parallel to this chemistry bench work, I used modern density functional theory to rationalize the regioselective ring-opening reactions of activated aziridines. The second part of my PhD thesis focused on the use of fingerprinting techniques to assess series of anticancer metal complexes, especially FTIR spectroscopy coupled to principal component analysis. FTIR on whole cells allows to acquire a global signature of the effects arising upon treatment of the cells. Comparing theses signatures within a chemical helps to identify potential leads.